| Basic Facts. VetGen has discovered
a linked DNA marker to a required genetic determinant of juvenile renal
dysplasia (JRD) in these three breeds. There is strong linkage between
this marker and the defective gene such that about 95% of the definitely
affected dogs in these breeds have one or two copies of an allele we have
called M (standing for mutant). At this marker locus, there is only one
other allele called N (for normal). The population frequency of the M
allele in the three breeds is about 30%.
Usefulness of Test. There is a high level of association of the M
marker with a JRD determining gene. Depending on whether our marker is
associated with a dominant-determinant or a recessive -determinant gene of
JRD, the degree of predictability of the M marker for JRD susceptibility
will vary a little. We have selected 80% as a conservative estimate of the
predictability.
The simplest way to understand the value of this test is to consider
the following. If you breed such that you produce an N/N puppy, you will
have an 80% probability that you have produced a genotype that can't get
JRD. Restated, you have decreased the risk of your puppy getting JRD by
80%.
In the very simplest of terms, breeding away from the M marker
significantly reduces the risk of JR puppies you produce.
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